Blogroll: Inviting ire and iron

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Cellular Iron Metabolism – The IRP/IRE Regulatory Network

Iron is the most abundant transition metal in cellular systems and is an essential micronutrient required for many cellular processes including DNA synthesis, oxidative cell metabolism, haemoglobin synthesis and cell respiration. Despite iron being an absolute requirement for almost all organisms, caution should be taken with an inappropriate disequilibrium in iron levels because excess iron is...

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Rapid kinetics of iron responsive element (IRE) RNA/iron regulatory protein 1 and IRE-RNA/eIF4F complexes respond differently to metal ions

Metal ion binding was previously shown to destabilize IRE-RNA/IRP1 equilibria and enhanced IRE-RNA/eIF4F equilibria. In order to understand the relative importance of kinetics and stability, we now report rapid rates of protein/RNA complex assembly and dissociation for two IRE-RNAs with IRP1, and quantitatively different metal ion response kinetics that coincide with the different iron response...

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Iron regulates mRNA translation initiation through RNA iron responsive element (IRE)

Iron regulates mRNA translation initiation through RNA iron responsive element (IRE) By Jia Ma Advisor: Professor Dixie J. Goss The non-coding IRE-RNA structure, a 30 nt stem loop structure, regulates synthesis of proteins in iron trafficking, cell cycling, and nervous system function. IRE-RNA binding with iron regulatory protein (IRP) proteins inhibits ribosome accessing mRNA. Increasing iron ...

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Inviting affordances and agency

Recently several authors have suggested that affordances are not mere possibilities for action but can also invite behavior. This reconceptualization of affordances asks for a reconsideration of the ecological approach to agency. After a portrayal of the role of agency in ecological psychology, we draw upon phenomenology to reveal what it means for an agent to be invited by affordances. We sket...

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Inviting pain

The role of pain in the practice of self-injury is not straightforward. Existing accounts suggest that self-injury does not cause 'physical' pain, however self-injury is also said to alleviate 'emotional' pain by inflicting 'physical' pain. This paper explores these tensions using sociological theories regarding the socio-cultural and subjective nature of pain. Analysis derives from in-depth, l...

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ژورنال

عنوان ژورنال: Nature Chemistry

سال: 2014

ISSN: 1755-4330,1755-4349

DOI: 10.1038/nchem.1929